Doctoral Thesis
Neueste Zugänge
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Rayleigh-Taylor turbulence with mean shear and interface tension
(2024)Rayleigh-Taylor (RT) turbulence originates at the interface between two fluid layers in the presence of an unstable density stratification \citep{rayleigh1882investigation,taylor1950instability,fermi1953taylor}. In nature, RT turbulence is usually influenced by additional factors. Firstly, the two fluid layers may move at different velocities in the horizontal direction so that a mean shear compounds the unstable density profile. Secondly, ...Doctoral Thesis -
Effects of creep on the interaction between TBM, lining and rock
(2024)Mechanised tunnelling through squeezing ground is very demanding because the space available to accommodate ground deformations is limited. If the converging ground closes the shield gap in the machine area, a pressure starts to develop upon the shield and the tunnel boring machine (TBM) might get stuck. Behind the machine, if ground deformations are prevented by a stiff lining, a prohibitively high rock pressure develops, and the lining ...Doctoral Thesis -
Kinetic Field Theory: a new formalism for microscopic perturbation theory
(2024)This thesis provides a general construction of the Kinetic Field Theory (KFT) framework and its microscopic perturbation theory for any classical physical system which can be described by a Hamiltonian. The generating functional of KFT is constructed based on a definition of phase space in terms of the cotangent bundle of configuration space and utilizing methods borrowed from the path integral formulation of classical mechanics. From it, ...Doctoral Thesis -
Structural and Functional Studies of Organic Anion Transporting Polypeptides OATP1B1 and OATP1B3
(2024)Doctoral Thesis -
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Sweet answers to the decades-long debates on the sucrose retardation
(2024)In the cement and concrete industry, the use of chemical admixtures is essential to improve either the properties for fresh pastes or the hardened concrete. However, many chemical admixtures cause cement hydration retardation in addition to their main effects. Among them, sugars are a family of retards which work specifically to extend the open time by delaying the onset of cement hydration. According to early studies, sucrose is a very ...Doctoral Thesis -
Bispecific Antibodies for the Treatment of Colorectal Cancer
(2024)Colorectal cancer (CRC) ranks as the second leading cause of cancer-related deaths globally, resulting in about one million people dying from it each year. At the time of diagnosis, most CRC cases are in an advanced stage, often with the cancer already spread to other organs. The current standard of care for these patients provides limited benefit, which is reflected in a 5-year survival rate of only 14%. This highlights the urgent medical ...Doctoral Thesis -
Luftgelagerte Spindel mit aktivem magnetischem Aktuator
(2024)Die Mikrosystemtechnik stellt hohe Anforderungen an die Fertigungsindustrie, insbesondere hinsichtlich der Realisierung kleiner Strukturen mit hoher Präzision und hoher Produktionsrate. Die Gewährleistung dieser Anforderungen erfordert präzise Komponenten, wobei insbesondere aerostatische Lager und mechatronische Elemente eine herausragende Rolle bei der Entwicklung hochpräziser Werkzeugmaschinenspindeln spielen. Diese Arbeit widmet ...Doctoral Thesis -
Modes of fitness increase during the aggregative multicellular development program of Myxococcus xanthus
(2024)In nature, environmental conditions are in constant flux. Organisms must dynamically respond and adapt to the presence of other biological entities as well as abiotic factors in order to survive and reproduce. Both cooperative and competitive interactions between organisms are common. Cooperation involves the expression of a trait that enhances the fitness of other individuals, and usually is costly to express. Conflict arises when the ...Doctoral Thesis -
Atmospheric Modeling for Enhancing Air Quality Prediction through the Integration of Inverse Modeling and Data-Driven Approaches
(2024)Air pollution holds significant importance due to its potential to jeopardize human health, negatively impact ecosystems, and result in economic losses. Understanding the internal mechanisms of air pollution is crucial for representing and forecasting air pollution, thereby enabling the mitigation of its adverse effects. Air quality models are powerful tools that predict air pollution by learning the innate physical and chemical processes ...Doctoral Thesis -
Receptor-Mediated Lysosomal Clearance of Endoplasmic Reticulum and Outer Nuclear Membrane
(2024)Doctoral Thesis -
Collagen Model Peptides: From Fundamental Investigations to Biological Applications
(2024)Collagen is a fundamental protein in all animals, providing structural support to cells and being involved in several cellular processes. Collagen model peptides (CMPs) are useful synthetic tools for the investigation of natural collagen. They have enabled the understanding of the conformational, mechanical and structural properties of collagen. Moreover, they have served for the development of functional materials or probe for biomedical ...Doctoral Thesis -
Modern Adaptive Experiment Design: Machine Learning Perspective
(2024)A key challenge in science and engineering is to design experiments to learn about some unknown quantity of interest. Optimal experimental design is a branch of statistics addressing the most informative allocation of experiments in order to infer an unknown quantity of interest. In this thesis, we fundamentally revisit and extend the methods and approaches of optimal design of experiments when our unknown quantity is a member of a ...Doctoral Thesis -
Metabolism Beyond Borders: Periplasmic Shikimate Pathway Enzymes in Pathogenic Bacteria
(2024)Doctoral Thesis -
Hyperbolic Metamaterials for High-Temperature Applications: Insights from Material Science
(2024)Hyperbolic metamaterials (HMMs) have gained significant attention due to their engineered extreme optical anisotropy, which allows for novel applications in sensing, photovoltaics, and health care. However, so far concerns about their limited thermal stability prevent the widespread implementation of HMMs in applications requiring high-temperature stability, such as thermophotovoltaics. This thesis addresses this challenge by examining ...Doctoral Thesis -
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Dark Sector Searches Weakly Coupled to Muons with the NA64μ Experiment at CERN
(2024)Many fundamental problems associated with the Standard Model of particle physics remain open today, among which are notable the strong CP problem, neutrino oscillations, or the matter-antimatter asymmetry of the Universe. One of the foremost open questions is the fundamental nature of Dark Matter, its origin, and its constituents. In this regard, particular interest has emerged in the explanation of its particle nature assuming mass ranges ...Doctoral Thesis -
Dynamic Models Of Escherichia Coli Metabolism: An Accurate Description Of Our Pathetic Thinking
(2024)Doctoral Thesis -
Epistemic Uncertainty Quantification and 3D Point Cloud Generation Using Explicit Generative Models
(2024)Doctoral Thesis -
Modular Navigation and Autonomy for Aerial Robots
(2024)A wealth of novel use cases and applications were made possible with the advent of Micro Aerial Vehicles (MAVs). Typical examples include aerial delivery, photogrammetry, inspection, and monitoring. The low hardware cost and general availability sparked an explosion in adoption not only in industry but also in the interest of the scientific community. A large body of research on flight control, state estimation, perception, navigation, ...Doctoral Thesis