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Die direkte fahrzeugseitige Messung der akustischen Schienenrauheit
(2024)Auf dem Weg zur umweltfreundlichen Mobilität wächst die Bedeutung des Schienenverkehrs. In Zukunft wird in der Schweiz ein weiterer Anstieg des Fahrgast- und Güteraufkommens im Schienenverkehr erwartet. Die steigende Nachfrage ist mit einer höheren Anzahl an Fahrten verbunden und es ist mit einer stärkeren Belastung der Schieneninfrastruktur zu rechnen. Dies stellt sowohl die Instandhaltung als auch den Lärmschutz vor neue Herausforderungen. ...Doctoral Thesis -
Physics-informed Probabilistic Artificial Intelligence for Enhanced Stability Predictions in Milling
(2024)With the widespread use of milling operations in the manufacturing industry, there has been a consistent desire to operate machine tools at their highest material removal rate capacity. Such an increase in productivity brings economic and environmental benefits by reducing the production time per item, subsequently leading to reductions in production costs, energy consumption, and related expenses. Despite this enduring aspiration, the ...Doctoral Thesis -
Carbon Isotopes and a Laser: Towards Simultaneous Measurements
(2024)The technique of laser ablation accelerator mass spectroscopy (LA-AMS) has been developed and improved over the past decade. It promises faster and cheaper high-resolution ¹⁴C records of various carbonate archives, but these benefits come at the cost of measurement precision. Here, a routine analysis protocol is proposed, which can reduce uncertainties by about 55%. It achieves this by measuring two parallel tracks, applying a Savitzky-Golay ...Doctoral Thesis -
Application of CLIR-MS in cell extract to map RNA-protein interactions in the context of SMN and FECH alternative splicing
(2024)The genetic information present in the DNA is transcribed into RNA, which must undergo a series of maturation steps before it can be translated into functional proteins. Splicing is a major step in pre-mRNA maturation, during which introns are removed and exons are ligated to form mature mRNAs. In higher eukaryotes, splice sites are often degenerate and additional factors are then required to allow the correct recognition of the 5’ and ...Doctoral Thesis -
Characterization of complexes required for mammalian transcriptional and post transcriptional gene regulation
(2024)Integrator (INT) is a large protein complex in metazoans, containing at least 16 subunits with a combined molecular weight of more than 1.5 MDa. This modular complex harbors dual enzymatic functionality with a cleavage module that has RNA endonuclease activity, and a phosphatase module with phosphatase activity. INT was initially identified as the 3’-end processing machinery for uridine-rich small nuclear RNAs (UsnRNAs). Later, it was ...Doctoral Thesis -
Post-transcriptional regulation orchestrated by Regnase RNA-binding proteins and m6A RNA methylation controls mast cell activation and homeostasis
(2024)Mast cells (MCs) are long-lived, tissue-resident immune cells with a central role in allergic responses. These cells can be activated by a wide range of stimuli leading to secretion of a large array of inflammatory mediators. Dysregulation of this process leads to allergies, asthma and anaphylaxis. Tight control is therefore critical to facilitate effective immune responses against external threats while minimizing harm to the host. ...Doctoral Thesis -
Mechanisms that link climate, soil properties and microbes to macroscale soil organic carbon dynamics: Insights from a geoclimatic gradient
(2024)Adequate representation of the soil organic carbon (SOC) cycle at the macroscale (km to global) is important in order to understand and predict the implications of SOC dynamics for the climate and our planet. Such adequate representation is challenging, because mechanistic knowledge about soils is derived from the much smaller mesoscale (mm to m). However, the dominant mechanisms and controls of the SOC cycle vary across scales. Therefore, ...Doctoral Thesis -
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Enhancing the Adoption of Additive Manufacturing in Industry using Principles of Agile Hardware Development
(2024)Additive manufacturing (AM) technologies are increasingly adopted for the development and production of physical products. Nevertheless, the industrial adoption of AM still represents a major challenge for manufacturing companies. AM can lead to significant implications at the adopting firm, with the potential to fundamentally transform existing value chains. One promising approach to overcome the uncertainty and complexity of AM adoption ...Doctoral Thesis -
Nonplanar Layered Morphologies
(2024)This thesis investigates the potential of nonplanar robotic 3D printing for architectural applications and develops novel methods to design nonplanar print paths for medium to large-scale robotic FDM 3D printing. Latest developments in additive manufacturing have opened new possibilities for 3D printing objects with unprecedented geometric complexity. However, these advancements are still hindered by the inherent limitations of current ...Doctoral Thesis